LPW Pyromania 17.3: Pick Your Poison was a professional e-wrestling supershow produced by Lords of Pain Wrestling and presented by its Pyromania brand (the 17.3 represents Pyromania's way of chronicling its shows, this event being Pyromania's sevententh cycle in its third show since the original LPW brand split). The event took place on Febuary 6, 2011 at the Newcastle Entertainment Centre in Newcastle, Australia.
At Pyromania 17.1, the red-hot Ken Ryans was able to get the better of Pyromania's first round draft pick Ultramarcus. After the match, Ryans pulled out the briefcase he won at Redemption (2008) from the Inferno 7 match in which he earned a world title match. He then announced that he would challenge Styxx for the LPW International Heavyweight Championship at Honor Roll. Ryans won the title, and was challenged by Ultramarcus to a Pick Your Poision match.